From North: Leave "Autostrada del Sole" Milan-Naples A1 (E35) motorway at the Valdichiana Bettolle pay toll exit junction and follow for Torrita di Siena and then Montepulciano.
From South: Leave A1 at the Chiusi-Chianciano Terme pay toll junction and follow for Chianciano Terme and then Montepulciano. Once you get to Montepulciano follow directions for "Centro Storico, Duomo, Ultimi parcheggi monumentali". Enter under the arch of the old town walls and park before entering on ZTL zone, because you can not enter in via San Donato. When there, you can drop off your luggage. Just before you enter Montepulciano or if you get lost please call.
Nearest Train station stop is Chiusi-Chianciano Terme, from which the public transport lines directly connect to Montepulciano. Driving from the station is about 25 minutes.
Closest airports are Florence Firenze Peretola and Pisa Galilei. Rome FCO Leonardo da Vinci is 2 hours and a half by car.
NB: on request we can arrange a taxi service with private driver.